Short story: Physics rules out the presence of "soul", "ghosts", and "afterlife".
Reason in brief: If the soul has to be present and driving our body functions, it has to be interacting strongly with matter, which our bodies are made of. We know very well, to a high degree of precision, how the particles of matter behave, which our bodies are made of, at the energies of room temperature. This knowledge rules out the presence of any other 5th force that interacts with matter at these energies. A similar argument can be extended to ghosts and by extension afterlife is ruled out.